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Real-time PCR was performed using an S1000 PCR instrument (Bio-Rad, Hercules, CA, USA) to quantify gene expression

Self-reported community sources describe GI events scaling with per-dose amount and brief fatigue scaling with total daily dose

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Ultimately, this review advocates for a paradigm shift in addiction medicine: one that recognizes the GBA not merely as a metabolic regulator, but as a critical entry point for future neurotherapeutic interventions

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