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In these patients, NAC induced low levels of oxidative stress in the hippocampus and increased intracellular GSH synthesis

However, chewing and tasting food stimulate saliva production

As discussed above, sufficient levels of thiamine in the brain are supported at the expense of other tissues, causing TD in these other tissues long before the TD occurs in the brain

One possible explanation is that this early renal deterioration may reflect a gradual worsening of underlying congestion, even before symptoms are clearly visible

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