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Some users say they've lost interest in things they once enjoyed: food, obviously, but also socializing, sex, alcohol and even favorite TV shows

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The largest trial of ERAs, SONAR, including 2648 participants with type 2 diabetes and proteinuric CKD, demonstrated that atrasentan on top of RAS inhibition significantly lowered the risk of a doubling of serum creatinine or ESKD compared with placebo by 35% [75]

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Because ischemic optic neuropathy can present with sudden vision loss, which may be permanent, early recognition of symptoms and prompt ophthalmologic evaluation may be especially important for patients at higher baseline risk. More than four in five cases of ischemic optic neuropathy are estimated to be the non-arteritic anterior form

Again, the relatively low incidence of certain pulmonary disorders and respiratory adverse events lowered statistical power