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For instance, the promoter regions of inflammation-related genes (e.g., IL-6 and TNF-) in patients with gouty arthritis exhibit hypomethylation, potentially promoting inflammation directly and independently of hyperuricemia (Tseng et al., 2020)

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This helps align expectations and promotes shared ownership of benefits and side effects

More specialized testing, such as skin biopsies to measure small fiber density or quantitative sudomotor axon reflex testing (QSART) to assess sweat gland function, is typically needed for accurate diagnosis

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While this growth creates massive opportunity, it also brings intense competition