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Under stimuli, CCL11 can be transported from blood to the brain across the blood-brain barrier (BBB) or be primarily secreted by activated astrocytes

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Contrary to expectations, the tripeptide has extremely low bioavailability through injections

The less efficient oxygen transport can also cause fatigue and weakness

Since semaglutide further slows gastric emptying as part of its mechanism of action, patients with pre-existing gastroparesis may experience worsening of symptoms including nausea, vomiting, bloating, and abdominal discomfort