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Description

Since polyphenols can act as PAINS in biochemical assays (autofluorescence, redox cycling, aggregation, metal chelation), in-vitro hits without orthogonal validation were downgraded

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The cleavage enzyme can be selected from Yeast ubiquitin hydrolase (YUH1) and the like

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The superscript numerals of each circular element indicate the corresponding referenced studies

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