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The physicochemical properties of suppositories prepared with different water contents, including melting behavior, mechanical hardness, disintegration time, stability, and content uniformity, were systematically evaluated and are summarized in Table S1 and Fig

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In addition, further consideration might be given to the counteraction of increased liver values of interleukin-6, tumor necrosis factor alpha and interleukin-1[25], and the relation with counteracted tumor cachexia[18], muscle wasting, increased pro-cachectic and pro-inflammatory mediators, and changes in the expression of forkhead box O3, phosphorylated protein kinase B, phosphorylated mammalian target of rapamycin, and phosphorylated glycogen synthase kinase 3[18]

Dupont et al

Hirschsprung disease is the most common cause of lower intestinal obstruction in neonates

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