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PMCID: PMC280272

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The most common side effects include nausea, upset stomach, constipation, fatigue, and headaches, which typically resolve with time

Infusion of pramlintide, a human amylin analogue, delays gastric emptying in men with IDDM

Thyroid C-cell tumours have been observed in rodent studies with GLP-1 receptor agonists, though the relevance to humans remains uncertain

Changes in hydration Many people on GLP-1 medications also notice: Reduced thirst Feeling full before drinking enough fluids Nausea that discourages drinking Less fluid intake, combined with slower digestion, often results in dehydration of the stool, further worsening constipation