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As IC/BPS might be multifactorial, future research should target different implicated pathways simultaneously and study the role of reactive oxygen species as a root cause in IC/BPS
Possible cellular responses are frequently mutually exclusive ones [13, 14]
In an animal model, -lipoic acid treatment was associated with reduced airway hyperresponsiveness, lower eosinophil counts, and IL-4 and IL-5 concentrations in BAL, improved pathology of the lungs, and lower intracellular ROS and NF-B DNA-binding activity [96]
A very recent study in healthy European volunteers assessed allulose effects at different doses on background of a 50-g sucrose test solution and observed a significant reduction of plasma glucose peaks at 30 min at the highest allulose doses of 75 and 10 g co-ingested with sucrose (Reference Franchi, Yaranov and Rollini38)
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