Proportion of basal and stimulated PBMC, as well as MFI of these cells, varied significantly over time, with pronounced changes around parturition and without any effect of CAR supplementation
[1] Important safety considerations include the risk of hypoglycaemia when combined with insulin or sulfonylureas, potential dehydration and acute kidney injury with severe gastrointestinal symptoms, and for semaglutide specifically, possible worsening of diabetic retinopathy in those with pre-existing disease
Data collection reflected routine clinical practice rather than mandatory assessments at prespecified time points, which may impact the amount of available data and its interpretation
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2 Establishes GLP-1RAs are engineered to overcome the rapid degradation of native GLP-1 through DPP-4resistant modifications and exposure-extending strategies such as fatty-acid acylation, enabling sustained receptor occupancy
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