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In conclusion, structures of ligand-bound CCKRs reveal that N98 2.61 , L356 7.39 , and Y360 7.43 in CCK1R contribute to the subtype selectivity of CCKRs for SR146131

In aged rat models, oral 5-amino-1mq capsules significantly improved myocardial mitochondrial function, reduced cardiomyocyte apoptosis, decreased myocardial injury markers (such as CK-MB, cTnI), enhanced cardiac contractility, and alleviated aging-related myocardial fibrosis

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