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CALORIC RESTRICTION SUPPRESSES SKELETAL TURNOVER Unlike white adipose tissue (WAT) and brown adipose tissue, BMAT, another type of fat tissue in the bone marrow that accounts for more than 10% of total body fat, has not been well defined until recently [45,46]

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Certain medical conditions and medications increase B12 requirements: Long-term use of metformin (diabetes medication) or proton pump inhibitors (PPIs for acid reflux) can impair B12 absorption [13] [14] Gastrointestinal conditions such as Crohn's disease, coeliac disease, or previous gastric surgery Autoimmune conditions beyond pernicious anaemia may affect B12 metabolism When to contact your GP : If you are taking B12 supplements or receiving injections but continue to experience symptoms, request a review