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Albumin binding to FcRn: distinct from the FcRn-IgG interaction

doi:10.1016/j.maturitas.2013.04.004 Herrou J, Mabilleau G, Lecerf JM, Thomas T, Biver E, Paccou J

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The four-pathway approach activates mechanisms that single or dual agonists cannot reach, potentially overcoming resistance that develops with prolonged use of less comprehensive compounds

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The problem we as clinicians are faced with is that melanoma in situ, lentigo maligna type and variants such as lentiginous melanoma, are very slow growing and can be extremely difficult to distinguish from benign solar lentigines