In addition, Akt phosphorylation was suppressed by either ESI-09 (Epac inhibitor) or LY294002 (PI3K inhibitor) in cardiac fibroblasts (Phosri et al., 2017) and in H9c2 cells ( Figure 5 ), suggesting that both PI3K and Akt serve as downstream effectors of Epac-mediated GLP-1R signaling in the heart
Referencias de contexto de investigacin
Ganguly D, Chamilos G, Lande R, Gregorio J, Meller S, Facchinetti V, et al
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biologically-oriented common variant burden profiling reflects polygenic modulation of key pathways such as inflammation, lipid metabolism, mitochondrial function and synaptic integrity
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