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In PCOS where insulin resistance is present in up to 80% of affected women regardless of body weight GLP-1 agonists have demonstrated measurable reductions in free testosterone, improved menstrual regularity, and significant metabolic benefit

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Women who are pregnant, planning pregnancy, or breastfeeding should avoid the compound entirely due to unknown effects on fetal and infant development

TB-500 safety data is less extensive but similarly suggests good tolerability in preclinical models

Consult a licensed healthcare provider before proceeding

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