If a patient cannot maintain hydration for more than 24 hours, our escalation pathway requires an immediate suspension of treatment and a clinical review to protect the biological health of the kidneys
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Additionally, there had been data showing that mice with GIP receptors knocked out didnt gain as much weight on a high-fat diet, suggesting to the field that blocking GIP could be a way to treat obesity
Example: If your pre-meal reading is typically 145 mg/dL (8.0 mmol/L) and your 2-hour after-meal reading is 210 mg/dL (11.7 mmol/L), these are above target
Based on the populations studied in clinical trials to date, retatrutide has been investigated primarily in adults living with obesity defined as a body mass index (BMI) of 30 kg/m or above as well as in those who are overweight (BMI 27 kg/m or above) with at least one weight-related comorbidity, such as type 2 diabetes, hypertension, or dyslipidaemia
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