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In summary, GLP-1 and GLP-1R show expression in a variety of tissues and the best-studied and most currently clinically relevant effects of GLP-1 is its ability to act as an incretin hormone and reduce appetite, given the global prevalence of T2D and obesity

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It's related to the sulphur-containing amino acids (cysteine, glycine, glutamic acid) that make up glutathione

The peptide works through multiple pathways: stimulating angiogenesis (new blood vessel formation), enhancing osteoblast activity, and reducing inflammation at injury sites

Gremlin 1, frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis