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Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

Valanejad, L

doi: 10.1002/j.1939-4640.1996.tb01830.x 112 AgarwalACannarellaRSalehRHarrazAMKandilHSalvioGet al

Its hallmark pathological features including cartilage degradation, subchondral bone sclerosis, osteophyte formation and synovial inflammation, are fueled by a complex interplay of inflammatory cascades, oxidative stress, and mechanical stress imbalance (57)

Specifically, curcumin enhanced phosphorylation of CLASP2 at Ser1025, which strengthened microtubule anchoring at the Golgi and improved Golgi ribbon organization (Figure 4A, F, G)

Typically, DPP-4 inhibitors are well-tolerated