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Excess iron catalyzes the aggregation and hyperphosphorylation of -amyloid and tau proteins, which are the major pathologies of AD, contributing to senile plaques and neurofibrillary tangles (Levi et al., 2024)

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Since body size is a major determinant of LA size, LA volume should be indexed to a measure of body size to allow meaningful comparison." "Even when the effects of body size were taken into account, these data showed significant breed differences for LA volume