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In this study, 75% of patients had high IFN signature at baseline

In this regard, GLP-1 treatment leads to decreased expression of macrophagespecific markers for M1 (inducible NOS (iNOS), IL6 and TNF) and enhances expression level of M2-marker genes, including arginine1, macrophage galectin-1 (MGL-1), IL10, as well as mannose receptor-1 (MRC-1)

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Glutathione helps inhibit this enzyme and reduces oxidative stress, which together slow down excess pigment formation

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