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10.1111/jne.12461 20 FryeR

Weeks 2 to 3: initial signals This is when the first consistent changes typically emerge

The consequence of T cell activity in AD appears to be predominantly detrimental, as T cells secrete IFN- and TNF, which further activate microglia to a neurotoxic phenotype and directly induce neuronal death or synapse loss

Post-surgical patients almost universally require B12 supplementation, often by injection