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It is unclear whether GIPR agonism enhances weight loss because GIP itself does not affect food intake or energy expenditure, GIPR antagonists induce weight loss in mice and non-human primates (9), and tirzepatide does not cause weight loss in obese Glp1r / mice (10)
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10.3389/fmed.2024.1388045 160 WebbR
Exceptions to these are species belonging to Streptococcus , Enterococcus and green sulphur bacteria
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