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Additionally, adequate maternal B12 is crucial for both mother and child, supporting maternal health and reducing the risk of neurological and metabolic complications

This distinction is critical: the preserved formula allows repeated doses to be drawn from the same multi-dose vial without risk of contamination, provided proper aseptic technique is maintained

Peer review Peer review information Nature Reviews Drug Discovery thanks Kevin Gardner and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

The agencys modern-day role was defined in 1962, after thalidomide caused birth defects in thousands of babies around the world

Neurological benefits including improved outcomes in demyelinating disease models point to CNS effects

By considering the pharmacokinetic factors that determine the dose-concentration relationship, it is possible to individualize the dose regimen to achieve the target concentration