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Activation of MC1R in melanocytes stimulates tyrosinase activity and eumelanin production, leading to skin pigmentation (tanning) independent of UV exposure

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GLP-1 receptor agonists and dual GLP-1/GIP receptor agonists: strengthened warnings on acute pancreatitis, including necrotising and fatal cases [Internet]

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In clinical trials, nausea occurred in 24-43% of patients across the 5-15 mg dose range, making it the most common side effect

This analysis supports the hypothesis that nausea suppression by GIPR agonism (57, 65, 69) contributes to the better tolerability profile of tirzepatide (15 mg) at doses 6.25x higher than semaglutide (2.4 mg)