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This study demonstrates that metformin inhibits oxidative phosphorylation in CRC cells, supporting metformin-mediated inhibition of complex I as a potential mechanism underlying its radiosensitising effects

However, it is important to understand that 24 weeks, while substantial for clinical trials, provides limited information about safety with years-long continuous use

Semaglutide and B12 create a well-rounded approach to weight loss

it does not directly modulate systemic hormonal axes in research models

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These conditions, along with polypharmacy, contribute to poor oral health, tooth loss, reduced salivary flow, and complications like dry mouth and dysgeusia