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In experimental autoimmune encephalomyelitis (a model of multiple sclerosis), berberine reduces the permeability of the blood-brain barrier and inhibits the activity of matrix metalloprotease 9 (MMP-9) in the cerebrospinal fluid and the brain of model mice (Ma et al., 2010)

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To further investigate the effects of HC on cellular redox homeostasis, the GSH/GSSG ratio, a hallmark of a more oxidized intracellular redox state (Zitka et al., 2012), was measured

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