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A direct association between symptomatic improvement and changes in GLP-1 levels was therefore not seen in this study

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2.15 Patient recruitment and ethics Ethical approval for patient sample collection for this study was granted by the Joint St

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Kundu R, Narean JS, Wang L, Fenn J, Pillay T, Fernandez ND, et al

Skeletal muscle dysfunction The molecular basis of insulin resistance in PCOS is unique and tissue specific and involves increased insulin-dependent serine phosphorylation of insulin receptors, impairing insulin signalling in skeletal muscle 151 , a distinguishing feature not present in other insulin-resistant conditions like obesity and T2DM 152