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After bariatric surgery we learned that metabolic improvement occurred long before significant amounts of fat mass have been lost

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These factors include increased accumulation of advanced glycation end products (AGEs), chronic inflammation due to increased proinflammatory cytokines, and bone microvascular lesions with decreased vascular flow and increased bone fragility

Research-grade preparation requires sterile reconstitution under low-light conditions, immediate refrigeration at 28C, and use within 14 days of mixing

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