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Active and passive smoking in relation to lung cancer incidence in the Womens Health Initiative prospective cohort study

Cancer Res Treat 50(2):445460 Griesinger F et al (2019) Efficacy and safety of first-line carboplatin-versus cisplatin-based chemotherapy for non-small cell lung cancer: A meta-analysis

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What NAPQI does: Directly binds to and damages cellular proteins Depletes glutathione rapidly Generates oxidative stress which damages DNA Triggers cell death Damages mitochondria, disrupting energy production NAPQI crosses the placenta and depletes fetal brain glutathione at doses below those causing maternal liver toxicity

Hepsin levels remained stable at 0.5 h post-treatment with 400 mg/kg APAP, comparable to those in saline-treated control livers

In summary, the present study highlights the impact of APP treatment on serum in vitro