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life expectancy is still below that of other countries similar in income and size, with an average lifespan of 78.4 years, compared to 82.5 years elsewhere

not recommended for use with DPP-4 inhibitors Common side effects : Gastrointestinal symptoms (nausea, vomiting, diarrhea) that typically diminish with continued use and proper dose titration Referral to endocrinology or obesity medicine specialists is appropriate for complex cases, including patients with multiple failed therapies, significant comorbidities, or those requiring comprehensive weight management programs

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Third, the typical metabolic defects of patients with T2DM such as impaired insulin secretion and insulin resistance can be mimicked in animals by a progressive loss of -cells [14]