Recent work demonstrated that sEVs loaded with semaglutide or tirzepatide crossed the gut barrier intact and produced significant 4-hour post-prandial glucose reductions in mice without inducing detectable anti-drug antibodies, underscoring their innate immune stealth [174]
A majority of participants reached clinically transformative thresholds, with more than half losing at least one-fifth of their baseline weight and roughly one in four achieving reductions of 30% or more
Dr Bhavesh Kotak, head medical affairs at the company described the growing girth of the problem: the country faces one of the worlds largest diabetes burdens, with over 100 million adults living with the condition and about 130 million pre-diabetic. A note from the company quotes these numbers from a ICMRINDIAB study which estimates diabetes prevalence at 11.4 per cent, with nearly four in ten adults experiencing abdominal obesity
Telogen effluvium explained Telogen effluvium is a form of hair loss involving hair thinning or an increase in hair shedding
10.1152/ajpendo.00464.2009 14 PeriK.AbranD.HabiA.AbribatT
The new study, known as the SELECT trial, found weight loss to be in the lower end of this range, in part due to variations in its study cohort: People who are more overweight when they begin taking the drugs lose more weight quickly
