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Many traditional vitamin C serums are abrasive, drying, or destabilized, which leads to irritation or oxidation

This aligns with the drug's 7-day half-life creating sufficient accumulation

Some users choose to take additional B12 sublingually rather than relying solely on the injected form in their tirzepatide

If a product or provider does not clearly explain the route, do not guess

Yamamuro T, Kawabata T, Fukuhara A, Saita S, Nakamura S, Takeshita H, Fujiwara M, Enokidani Y, Yoshida G, Tabata K, et al

But it does mean you're accepting risks that don't exist with topical application, for benefits that may not be meaningfully greater