GLP-1 receptor binding provides glucose-dependent insulin secretion and appetite suppression, while GIP receptor activation enhances postprandial insulin response
That can make intoxication feel delayed, prolonged and, in some cases, people feel off the next day. Theres also a basic but often overlooked factor: People on GLP-1s tend to eat and drink less
A single missed dose will cause a temporary dip in plasma levels but should not significantly disrupt results
GLP-1R is expressed in the brainstem nucleus tractus solitarius, in the hypothalamic arcuate nucleus, in the vagus nerve, in the stomach, and in the heart
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This is important because GLP-1 drugs were originally designed to have a long half-life in blood to maximise their efficacy in the treatment of diabetes which prevents them from entering the brain (Hlscher)