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GLP-1 receptor binding provides glucose-dependent insulin secretion and appetite suppression, while GIP receptor activation enhances postprandial insulin response

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That can make intoxication feel delayed, prolonged and, in some cases, people feel off the next day. Theres also a basic but often overlooked factor: People on GLP-1s tend to eat and drink less

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A single missed dose will cause a temporary dip in plasma levels but should not significantly disrupt results

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GLP-1R is expressed in the brainstem nucleus tractus solitarius, in the hypothalamic arcuate nucleus, in the vagus nerve, in the stomach, and in the heart

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This is important because GLP-1 drugs were originally designed to have a long half-life in blood to maximise their efficacy in the treatment of diabetes which prevents them from entering the brain (Hlscher)

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