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This undergoes two-electron oxidation (and oxygen transfer) by an H 2 O 2 molecule to an oxyferryl porphyrin -cation radical active form of the enzyme (known as Compound 1), represented by Enz-[Por+.-Fe(IV)=O] in Equation 2

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These effects are mainly attributed to the activation of Nrf2

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Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1