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GTP Cyclohydrolase I Expression, Protein, and Activity Determine Intracellular Tetrahydrobiopterin Levels, Independent of GTP Cyclohydrolase Feedback Regulatory Protein Expression. The Journal of Biological Chemistry , vol

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Importantly, the loss of TBC1D9B also caused lysosomes to accumulate in the cell periphery, e.g., proximal to focal adhesion points, with a concomitant depletion of lysosomes within the perinuclear region (Fig