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Persistent redness affecting the entire face uniformly suggests systemic copper accumulation rather than localized irritation

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the proportion of positively stained cells was divided into four grades, namely (1) 025%, (2) 2650%, (3) 5175%, and (4) 76100%

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Histopathological examination using H&E and AB-PAS staining revealed severe pathological changes in the colonic epithelium of DSS-treated mice