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The benefits of triple agonism extended also to MASLD in a subgroup of 98 people, fat content normalised in approximately 90% of people receiving the highest retatrutide doses [82]
Compared to other second- or third-line antidiabetic agents, DPP-4 inhibitors have not been shown to increase the risk of lung cancer [48]
The study was approved by the Committee on Human Subjects, Joslin Diabetes Center (Boston, Massachusetts, USA)
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GCG activation suppresses endogenous hepatic lipid production by inhibiting lipogenic enzymatic pathways while simultaneously enhancing mitochondrial oxidative lipid catabolism, thereby promoting lipid catabolism and reducing hepatic triglyceride content [18]