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14.2 BYDUREON BCISE Glycemic Control Trials in Adults with Type 2 Diabetes Mellitus BYDUREON BCISE versus BYETTA, Both as Monotherapy or as Add-on to Metformin, a Sulfonylurea, a Thiazolidinedione, or Combination of Oral Agents A 28-week, randomized, open-label comparator-controlled trial was conducted to compare the safety and efficacy of BYDUREON BCISE to BYETTA in adult patients with type 2 diabetes and inadequate glycemic control with diet and exercise alone or with oral antidiabetic therapy, including metformin, a sulfonylurea, a thiazolidinedione, or a combination of any two of these therapies (Trial 1 - NCT01652716)

85 GPX2 is poorly expressed in healthy lungs, whereas GPX2 markedly increases in the airway epithelium in response to cigarette smoke exposure and inflammation

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Obvious neurological and/or cardiovascular symptoms may represent a culmination of gastrointestinal beriberi, probably triggered by challenges that increase metabolic demands or decrease intracellular transport of thiamin, such as stress, infection, trauma, drug administration