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Due to structural associations, A 2A R activation can inhibit Gi/o protein (G protein subunit, which inhibits adenylyl cyclase activity and thereby decreases cAMP levels) coupled with D 2 R, further validating the existence of the A 2A R-D 2 R heteroreceptor complex [34,35]

(2024) MMWR Morb Mortal Wkly Rep, 73: 917

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Some mechanistic data suggest potential direct effects

Moreover, GIP seems to attenuate GLP-1R-agonism mediated adverse effects thus making more tolerant this therapy and favoring WL