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It acts similarly to natural GLP-1 by promoting insulin release, inhibiting glucagon secretion, delaying stomach emptying, and promoting satiety when administered as an oral tablet (brand name Rybelsus) or as a weekly injection
Thus, although GIPR in the AP is required for the weight loss effects of GIPR agonists, it is not the target of therapeutic GIPR antagonists, supporting recent findings that Gipr KO in GABAergic neurons also abolished responses to GIPR agonism but not antagonism 6
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Some patients may regain weight after stopping if appetite returns and lifestyle habits are not maintained
While promising weight loss, Ozempic has side effects to be aware of, like GI issues