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The main drawback of pentavalent antimonials is their severe toxicity, including cardiotoxicity (e.g., ventricular tachycardia, prolonged QTc interval), pancreatitis, pancytopenia, and nephrotoxicity

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, using high-resolution respirometry) have found reduced mitochondrial oxygen consumption rates and membrane depolarization, indicating intrinsic mitochondrial dysfunction (61)

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In summary, acquiring a thorough knowledge of the mechanisms and determinants linked to renal aging is crucial for the prevention and management of age-related renal diseases