This tri-receptor activity is what fundamentally distinguishes Retatrutide from all preceding incretin research compounds, including dual agonists like Tirzepatide (GLP-1R/GIPR) and single agonists like Semaglutide (GLP-1R only), and is the basis for its position at the leading edge of metabolic peptide research
EBioMedicine 93 , 104642 (2023)
Just like coming off any other chronic medication, stopping a GLP-1 means the support it provided will no longer be there
SCFAs are more than metabolic waste: butyrate is the preferred fuel for colonocytes and supports mucosal energy needs, whereas all three acids tighten epithelial junctions and stimulate mucin secretion, thereby reinforcing the intestinal barrier [57,58]
Try adding: A drizzle of olive oil on vegetables or salads A small handful of almonds, walnuts or pistachios A tablespoon of nut butter with fruit or in a smoothie A quarter of an avocado to a meal or snack 4
Catherine Schaefer, physician assistant with Shed It
