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RAAS inhibitors are cornerstone therapies for hypertension, heart failure, and post-myocardial infarction, with both systemic and local cardiac effects contributing to inflammation and fibrosis

According to the FDA-approved prescribing information, gastrointestinal adverse reactions (nausea, vomiting, diarrhea) occur in up to 43% of patients taking Mounjaro and 37% of patients taking Zepbound, with higher rates during dose escalation phases

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We cover that in more practical detail in our newer guide, especially the role of internal resistance, voltage sag, heat, wiring, and real-world pack behavior

J Immunol 198(4):13951402