Available in multiple dosages via infusion or injection
[2] High-dose intramuscular administration creates a tissue depot that releases vitamin D slowly over weeks, potentially enabling a single injection to lift serum 25-hydroxyvitamin D levels into the sufficient range in severe deficiency and to potentially support bone mineralisation, neuromuscular function, and secondary hyperparathyroidism reversal while bypassing the gastrointestinal tract
We recommend contacting your insurance provider directly to verify coverage.
Fu et al (1988) B vitamins suppress spinal dorsal horn nociceptive neurons in the cat D Bonke, B Nickel (1989) Improvement of fine motoric movement control by elevated dosages of vitamin B1, B6, and B12 in target shooting Dakshinamurti et al (1990) Influence of B vitamins on binding properties of serotonin receptors in the CNS of rats Jurna et al (1990) Acute effects of vitamin B6 and fixed combinations of vitamin B1, B6 and B12 on nociceptive activity evoked in the rat thalamus: dose-response relationship and combinations with morphine and paracetamol Magana-Villa (2013) B-vitamin mixture improves the analgesic effect of diclofenac in patients with osteoarthritis: a double blind study Syed et al (2013) Vitamin B12 Supplementation in Treating Major Depressive Disorder: A Randomized Controlled Trial L Shen et al (2015) Associations between B Vitamins and Parkinsons Disease Dong et al (2015) Efficacy of Supplementation with B Vitamins for Stroke Prevention: A Network Meta-Analysis of Randomized Controlled Trials Kamchatnov et al (2015) The use of neurobion in neurological practice B Jayabalan, L Low (2016) Vitamin B supplementation for diabetic peripheral neuropathy Rathod et al (2016) Novel insights into the effect of vitamin B12 and omega-3 fatty acids on brain function Ebrahimi et al (2018) Effect of vitamins B1, B6, and B12 (Neurobion) on Diisopropylfluorophosphateinduced Delayed Neuropathy in Mice Togha et al (2020) Suppression of Menstrual-Related Migraine Attack Severity Using Pyridoxine, Thiamine, and Cyanocobalamin: A Quasi-Experimental Within-Subject Design S Baltrusch (2021) The Role of Neurotropic B Vitamins in Nerve Regeneration H Nguyen, M-S Kim (2022) The role of mixed B vitamin intakes on cognitive performance: Modeling, genes and miRNAs involved Paez-Hurtado et al (2023) Mechanisms of action of vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) in pain: a narrative review 05/02/2024 LU Lyudmyla U
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Contraindications include Lebers hereditary optic neuropathy, severe kidney disease, known cobalt or cobalamin allergy, and polycythemia vera
