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Combined with our trafficking and insulin release results, these data show a canonical role for -arrestin recruitment in promoting GLP-1R endocytosis and desensitization

Slower titration equals better tolerance

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Gastroesophageal reflux disease (GERD) is a commonly reported cause of esophagitis in humans, but it is rarely reported in cats when not associated with general anesthesia.24, 33 The true incidence is unknown, and diagnosis may be hampered by scant knowledge about the clinical presentation and diagnosis