5 However, its most important antioxidant effect is thought to be as a precursor for glutathione (GSH), 6 a tripeptide made from the amino acids glutamate, glycine and cysteine, and the bodys major antioxidant
TamtajiORHeidari-SoureshjaniRMirhosseiniNKouchakiEBahmaniFAghadavodEet al
These routes of disulfide bond formation and resolution have been worked out most completely in Escherichia coli and are depicted in Figure 1
PHQ-9, Patient Health Questionnaire-9
M is grateful to UGC for Junior Research Fellowship and AS, AK and ST are thankful to CSIR for senior research fellowship
Importantly, tumors with LOH have lower measurable GPx-1 enzyme activity and increased accumulation of 8-hydroxydeoxyguanosine, a pro-mutagenic DNA-oxidation product, suggesting that LOH results in oxidative stress in these tumors