This is a standard model for testing procognitive compounds
(Biomed Res Int 2015): modulacin de 4,000+ genes en queratinocitos humanos
Published veterinary applications document no significant adverse events at standard research doses in canine subjects
A finished preparation should be visually transparent with a characteristic blue tint and no suspended particulate
The use of potent CYP 3A4 inhibitors (ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, troleandomycin, ketoconazole, itraconazole) with dihydroergotamine is, therefore contraindicated (see WARNINGS: CYP 3A4 Inhibitors)
Precaution in Pregnancy and Nursing: Evaluate the risk versus benefit for use during pregnancy or lactation