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The clinical evidence is striking

Lim, J

In many cases, the longer half-life of ROS provides an extended time for diffusion and consequently the power to succeed in sensitive sites within a cell where it can react with biomolecules far away from the location of its generation

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Later, similar observations were made in gastrointestinal tumors, neuroblastomas, renal tumors, thyroid tumors, and testicular tumors 125,126