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Semaglutide is a GLP-1 receptor agonist medication that is used to treat type 2 diabetes

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Theoretically, nanoparticles (NPs) encapsulating GLP-1RAs can significantly extend the drugs half-life and promote accumulation of the drug in the joint cartilage, thereby maintaining a high therapeutic concentration for an extended period and improving treatment efficacy

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UV-VIS spectrum analysis To determine the UVVIS spectra of the isolated melanins, 30 mg of melanin powders were dissolved in 2 mL of 1 M NaOH and diluted to 50 mL with deionized water