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It was originally created by researchers at the University of Arizona in Tucson, AZ, In the early 1990s to increase melanin production and serve as a potential protectant from ultraviolet (UV) light-induced skin cancers

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Interestingly, Larson and colleagues demonstrated that CGRP is expressed ectopically in mucus cells of ovalbumin (OVA)-sensitized Brown-Norway rats [150]

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